Peptide Pen Mito Boost

Mito Boost delivers 60mg MOTS-c in up to 18 longevity-enhancing, performance-boosting doses.

Product Name: Mito Boost Pen 

Formulation: 2.6 mL pre-filled pen 

Clicks per Pen: 240 

Total Amount: 60 mg MOTS–C 

Supplied with: 6 sterile needles (extras available) 

Description 

MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16–amino–acid mitochondrial–derived peptide (MDP) encoded within the mitochondrial 12S rRNA gene. 

Chemical Structure

Sequence: Met-Arg-Trp–Gln–Glu–Met–Gly–Tyr–Ile-Phe-Tyr–Pro–Arg–Lys–Leu-Arg (MRWQEMGYIFYPRKLR) 

Molecular weight: ~2,173 Da 

It is a linear peptide with no disulfide bonds or post–translational modifications in its native form. 

Mechanism of Action 

MOTS-C is transcribed and translated within mitochondria, then exported to the cytoplasm and nucleus where it acts as a retrograde signalling molecule. Its primary mechanism involves: 

Direct activation of AMP-activated protein kinase (AMPK) 

Increased expression of PGC-1a and downstream mitochondrial biogenesis genes 

Enhanced fatty acid ẞ-oxidation and glucose uptake 

Improvement of insulin sensitivity via reduced inflammatory signalling (↓ NF-kB, ↓ IL-6) 

Protection against metabolic stress, oxidative damage, and age-related mitochondrial decline 

Modulation of nuclear gene expression related to metabolism, proteostasis, and stress resistance 

By acting as a mitokine, MOTS-C coordinates mitochondrial-nuclear communication to optimize energy homeostasis, metabolic flexibility, and cellular resilience. 

Indications & Usage 

Mito Boost (MOTS-C) is used to support mitochondrial function and metabolic health. It is indicated for: 

Enhancement of mitochondrial biogenesis and energy production 

Support for fat oxidation, insulin sensitivity, and metabolic efficiency 

Assistance during age–related decline in physical performance and recovery 

Promotion of endurance, exercise capacity, and cellular resilience under metabolic stress 

Contraindications & Warnings 

Do not use if you have: 

Known hypersensitivity to MOTS-C or any excipient 

Active malignancy (theoretical concern regarding cellular metabolism enhancement) 

Severe uncontrolled liver or kidney disease 

Pregnancy or breastfeeding 

Age under 18 years 

Warnings 

Use only under medical supervision with periodic monitoring (e.g., glucose metabolism, liver function, clinical parameters). 

Not a substitute for lifestyle interventions or approved therapies for metabolic disorders. High doses may cause transient gastrointestinal discomfort or changes in energy levels. 

Discontinue immediately and seek medical attention if severe symptoms occur (e.g., severe abdominal pain, allergic reaction, or unexpected neurological changes). 

Dosage & Administration 

Subcutaneous injection only. 

Standard Dose: 5 mg (22 clicks) per injection 

(delivers exactly 5 mg based on pen calibration) 

Alternative Lower Dose: 3 mg (13 clicks) – for longevity/maintenance or sensitive protocols

Frequency: 2-3 times per week (e.g., Monday/Wednesday/Friday, or spaced around training/recovery days) 

Timing: Morning or pre-workout to maximize energy, stamina, and recovery support 

Cycle: Typically, 4-12 weeks on, followed by 4 weeks off to maintain efficacy

Optional Loading Phase: First 2-4 weeks: 5 mg 3×/week, then reduce to 2x/week or once weekly for maintenance 

Administration Instructions

Wash hands and prepare a clean surface. 

Attach a sterile needle. 

Dial the required number of clicks (e.g., 22 clicks = 5 mg). 

Clean injection site (abdomen or thigh) with alcohol swab. 5.Insert needle at 45-90° angle and inject slowly. 

Withdraw needle, dispose safely, and cap the pen. 

Rotate injection sites to minimize irritation. 

Always inspect solution before use: Do not inject if cloudy, discoloured, or containing particles. 

Side Effects 

MOTS-C is generally well tolerated across preclinical and early human studies. Reported reactions are uncommon and usually mild/transient, including: 

Mild injection-site irritation, redness, or itching 

Transient headache or light–headedness 

Temporary fatigue or changes in energy levels during initial use 

Rare mild gastrointestinal discomfort (nausea, bloating) 

If any severe or persistent symptoms occur (e.g., severe headache, abdominal pain, or allergic signs), discontinue use and contact your healthcare provider immediately. 

Storage & Handling 

Store either in refrigerator (fridge); never freeze or in a cool dry place (≤25-30°C / 77-86°F). Keep pen capped and protected from light and heat. 

After first use: Same storage conditions. 

Keep out of reach of children. 

Discard if expired or solution appears abnormal. 

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